منابع مشابه
R/qtl: QTL Mapping in Experimental Crosses
SUMMARY R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in experimental populations derived from inbred lines. It is implemented as an add-on package for the freely-available statistical software, R, and includes functions for estimating genetic maps, identifying genotyping errors, and performing single-QTL and two-dimensional, two-QTL genome scans by ...
متن کاملCopulas in QTL mapping.
The standard variance components method for mapping quantitative trait loci is derived on the assumption of normality. Unsurprisingly, statistical tests based on this method do not perform so well if this assumption is not satisfied. We use the statistical concept of copulas to relax the assumption of normality and derive a test that can perform well under any distribution of the continuous tra...
متن کاملR/qtl: high-throughput multiple QTL mapping
MOTIVATION R/qtl is free and powerful software for mapping and exploring quantitative trait loci (QTL). R/qtl provides a fully comprehensive range of methods for a wide range of experimental cross types. We recently added multiple QTL mapping (MQM) to R/qtl. MQM adds higher statistical power to detect and disentangle the effects of multiple linked and unlinked QTL compared with many other metho...
متن کاملPrinciples of QTL Mapping
To date, most genetic progress for quantitative traits in livestock has been made by selection on phenotype or on estimates of breeding values (EBV) derived from phenotype, without knowledge of the number of genes that affect the trait or the effects of each gene. In this quantitative genetic approach to genetic improvement, the genetic architecture of traits of interest has essentially been tr...
متن کاملQTL mapping under ascertainment.
Mapping quantitative trait loci (QTL) using ascertained sibships is discussed. It is shown that under the standard normality assumption of variance components analysis the efficient scores are unchanged by ascertainment, and two different schemes of ascertainment correction suggested in the literature are asymptotically equivalent. The use of conditional maximum likelihood estimators derived un...
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ژورنال
عنوان ژورنال: Euphytica
سال: 2019
ISSN: 0014-2336,1573-5060
DOI: 10.1007/s10681-019-2440-3